Mefenamic Acid Side Effects: What You Need to Know

When you take Mefenamic Acid, a nonsteroidal anti-inflammatory drug (NSAID) used mainly for menstrual pain and mild to moderate inflammation. Also known as Ponstel, it works by blocking pain signals at the source—like prostaglandins—that cause cramps, swelling, and fever. But like all NSAIDs, it doesn’t come without risks. Many people use it for period pain because it’s effective and fast-acting, but not everyone talks about what happens after the pill kicks in.

The most common side effects of Mefenamic Acid are stomach-related: nausea, heartburn, bloating, or diarrhea. These aren’t just minor inconveniences—they can be serious enough to make you stop taking it. About 1 in 5 users report digestive upset, and in rare cases, it can cause ulcers or internal bleeding, especially if taken long-term or with alcohol. It’s not just about the stomach, either. Some people get dizziness, headaches, or ringing in the ears. Less often, it affects the liver or kidneys, especially if you’re already on blood pressure meds or have existing health issues. If you’re over 65, or have a history of stomach problems, you’re at higher risk. That’s why doctors don’t recommend it for long-term use.

What makes Mefenamic Acid different from ibuprofen or naproxen? It’s more targeted for menstrual cramps, but that doesn’t mean it’s safer. Studies show it carries similar cardiovascular risks as other NSAIDs—higher chance of heart attack or stroke with prolonged use. It’s also not safe during the third trimester of pregnancy, and it can pass into breast milk. If you’re using it for cramps, you might not think about these risks, but they’re real. And if you’re combining it with other painkillers, supplements like fish oil, or even herbal teas, you could be increasing your chances of bleeding or liver stress without even knowing it.

There’s no one-size-fits-all answer when it comes to pain relief. What works for your friend might cause you serious side effects. That’s why knowing the signs—like dark stools, swelling in your ankles, sudden dizziness, or yellowing skin—is critical. You don’t need to avoid Mefenamic Acid entirely, but you do need to use it wisely. The posts below give you real, practical advice on managing these side effects, comparing it to other pain meds, understanding how your body reacts, and making smarter choices when you reach for that pill. You’ll find guides on when to call your doctor, what to eat to protect your stomach, and how to spot the early warning signs before they become emergencies.