Indinavir is an older HIV protease inhibitor that used to be a core part of HIV treatment. It still works against the virus, but it has side effects and special rules that most newer drugs don’t. If you or someone you care for is on indinavir, these facts and tips will help you stay safe and get the most from treatment.
Indinavir blocks the HIV protease enzyme, stopping the virus from making new infectious particles. Doctors may use it when other options aren’t available or in specific combinations. Today it’s less common because newer drugs are easier to take and cause fewer problems, but indinavir still shows up in some treatment plans.
If you’re starting indinavir, expect your provider to explain monitoring: viral load and CD4 counts to track HIV, and labs for kidneys, liver, blood sugar, and lipids.
Biggest risk: kidney stones. Indinavir can cause crystals to form in urine, which hurts and can damage kidneys. Drink plenty of water — aim for around 1.5–2 liters a day unless your doctor says otherwise. Emptying your bladder often helps, too.
Other common issues: nausea, headaches, elevated bilirubin (which can cause yellowing of the skin), changes in blood sugar, and shifts in fat distribution. Tell your doctor about new muscle pain, dark urine, or sudden belly pain — those can be warning signs.
Drug interactions matter. Indinavir is handled by the liver enzyme CYP3A4, so some drugs lower its level and others raise it. Examples to watch for: rifampin and St. John’s wort can reduce indinavir effectiveness. Avoid simvastatin or lovastatin with indinavir — they can cause dangerous muscle damage. Always check prescription, OTC, herbal, and recreational drugs with your clinic or pharmacist.
Take indinavir exactly as prescribed. Historically it was given as 800 mg every 8 hours on an empty stomach, but some regimens use different dosing when combined with boosters like ritonavir. Never change timing or dose on your own — small changes can hurt how well the drug works or raise side effects.
Simple daily habits make a big difference: stay hydrated, take blood tests as scheduled, report side effects early, and keep a current drug list ready for every provider visit. If you’re pregnant, breastfeeding, or have severe kidney or liver disease, discuss alternatives — your doctor will point you to safer, modern options when needed.
If you’re unsure about an interaction or a symptom, call your clinic. Indinavir can be effective, but it demands attention. With the right checks and common-sense habits, you can reduce risks and stay focused on treatment.
In my recent exploration, I've discovered the significant role Indinavir plays in the LGBTQ+ community. This antiviral medication is a reliable tool in the battle against HIV, a condition that disproportionately affects this community. By inhibiting the progression of the virus, Indinavir ensures a higher quality of life and longevity for those affected. It's heartening to see medical advancements like this being a beacon of hope for communities often marginalized. It's a clear reminder that inclusive healthcare isn't just a necessity, it's a right for everyone, regardless of their sexual orientation or identity.
Callum Laird | Jul, 21 2023 Read More